Tranexamic Acid

Tranexamic is an amino acid. In dermatology the effects of Tranexamic acid have been known for a long time, namely in the context of pigment disorders.

Tranexamic acid prevents UV-induced pigmentation by interfering with the structure of plasminogen and preventing the binding of plasminogen to the lysine-binding sites of keratinocytes. Consequently, there is less free arachidonic acid leading to a reduced ability to produce prostaglandins and thus decreased melanocyte tyrosinase activity and melanogenesis. Blocking of the Sc-uPA pathway may be another mechanism through which Tranexamic acid reduces hyperpigmentation. It is found to be similar to tyrosine in the part of its structure, which can competitively inhibit the activity of tyrosinase.

Tranexamic acid reduces hyperpigmentation, promotes lightening and an even skin tone and minimizes liver spots and age spots. It can also reduce the degree of skin tanning after UV exposure.